This population-based cohort study investigated the occurrence of familial astrocytoma among first-degree relatives of patients with astrocytoma diagnosed between 1985 and 1993 in the northern region of Sweden.
The 432 cases received a questionnaire.
They were asked to provide names and cancer diagnoses of first-degree relatives.
Of the 297 answering, a cohort was constructed of their 1,890 first-degree relatives (FDR).
A significantly increased risk [standardized incidence ratio, SIR=2.12,95% confidence interval (Cl)=1.18-3.49] was shown for developing primary brain tumors (PBT).
In 4.7% (141297) of the families, a PBT was found.
Interestingly, the increased risk was for astrocytoma only (SIR=3.12,95% CI 1.42-5.92), and not for other PBT (SIR 0.90,95% CI 0.18-2.64).
When the cohort was divided according to the median age of proband, most of the increased risk was restricted to the younger cohort (SIR=4.71,95% CI 1.52-10.99).
Surprisingly, a significantly decreased risk for breast cancer and colon cancer was shown.
The finding that the increased risk is restricted to astrocytoma only is a novel one.
This study implies that familial aggregation of astrocytoma exists ; the familial clustering occurs in a small fraction of astrocytoma, and might be explained by inherited factors.
Mots-clés Pascal : Astrocytome malin, Facteur risque, Epidémiologie, Etude familiale, Etude cohorte, Suède, Europe, Nord, Homme, Système nerveux pathologie, Système nerveux central pathologie, Gliome malin, Tumeur maligne, Parenté premier degré
Mots-clés Pascal anglais : Malignant astrocytoma, Risk factor, Epidemiology, Family study, Cohort study, Sweden, Europe, North, Human, Nervous system diseases, Central nervous system disease, Malignant glioma, Malignant tumor, First degree relatives
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0212655
Code Inist : 002B17E. Création : 16/11/1999.