This study was carried out to assess the validity of three testing methods of immunochemical occult blood according to the number of collection times as a means for colorectal cancer screening.
Four thousand six hundred and eleven asymptomatic individuals, who received both an immunochemical occult blood test with a three-day method and colonoscopy during a medical check-up, served as subjects for this study.
For evaluation of the desirable number of sampling times, we used the results of the first day for the 1-day method, the results of the first and second days for the 2-day method, and the results of three-consecutive days for the 3-day method.
Sensitivities and specificities of these three testing methods were evaluated.
Sensitivities and specificities for colorectal cancer were calculated to be 56% and 97% for the 1-day method, 83% and 96% for the 2-day method, and 89% and 94% for the 3-day method, respectively, showing a significant difference in sensitivity between the 1-day and the 2-day methods, as well as the 3-day method (p<0.01), and in specificity between the 1-day as well as the 2-day and 3-day methods (p<0.05).
These findings indicate that the immunochemical fecal occult blood test is useful for the diagnosis of colorectal cancer, and that 2-day testing is recommended as a means of screening for colorectal cancer.
Mots-clés Pascal : Carcinome, Côlon, Rectum, Dépistage, Sang, Fèces, Immunohistochimie, Répétition, Diagnostic, Colonoscopie, Evaluation performance, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Anatomopathologie, Endoscopie
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Medical screening, Blood, Feces, Immunohistochemistry, Repetition, Diagnosis, Colonoscopy, Performance evaluation, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Pathology, Endoscopy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0211981
Code Inist : 002B24E06. Création : 16/11/1999.