Four laboratories have participated in an external quality control assessment for the determination of 2-thiothiazolidine-4-carboxylic acid (TTCA).
TTCA is used as a biomarker for exposure to CS2.
Thirteen different urine samples were analyzed by each laboratory.
Ten of these were spiked with known amounts of TTCA, and had either a high or intermediate creatinine content.
Two samples without any TTCA were used as controls and one sample was a pool of samples of urine from five employees occupationally exposed to CS2.
The latter had unknown TTCA content.
For each sample, TTCA and creatinine concentration were determined.
The samples were supplied in three consecutive deliveries.
Several samples were offered more than once.
Thus, within-laboratory variability could be established for creatinine and TTCA determination and accuracy could be determined for TTCA analysis.
Within-laboratory variability was low for all laboratories for creatinine, although laboratory I) seemed to have a slight downward bias.
Accuracy for TTCA was good for all laboratories.
No significant mean deviation from the expected TTCA value was encountered.
There does not seem to be any clear influence of the TTCA concentration level of the samples on the accuracy and within-laboratory variability. (...)
Mots-clés Pascal : Carbone disulfure, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Marqueur biologique, Urine, Liquide biologique, Analyse quantitative, Etude multicentrique, Métabolite, Contrôle qualité
Mots-clés Pascal anglais : Carbon disulfide, Occupational exposure, Occupational medicine, Human, Biological monitoring, Biological marker, Urine, Biological fluid, Quantitative analysis, Multicenter study, Metabolite, Quality control
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0207398
Code Inist : 002B03L06. Création : 16/11/1999.