Background-A work force based case-control study of lung cancer was performed in non-silicotic subjects exposed to crystalline silica to investigate the association between silica dust and lung cancer excluding the influence of silicosis.
Methods-Two hundred and forty seven patients with lung cancer and 795 control subjects were enrolled, all of whom had been employed in the German stone, quarrying, or ceramics industries.
Smoking was used as a matching criterion.
Exposure to silica was quantified by measurements, if available, or otherwise by industrial hygienists.
Several indices (peak, average and cumulative exposure) were used to analyse the relationship between the level of exposure and risk of lung cancer as odds ratios (OR).
The risk of lung cancer is associated with the year of and age at first exposure to silica, duration of exposure, and latency.
All odds ratios were adjusted for these factors.
Considering the peak exposure, the OR for workers exposed to high levels (>=0.15 mg/m3respirable silica dust which is the current occupational threshold value for Germany) compared with those exposed to low levels (<0.15 mg/m3) was 0.85 (95% CI 0.58 to 1.25).
For the time weighted average exposure the OR was 0.91 (95% CI 0.57 to 1.46).
The OR for the cumulative exposure was 1.02 (95% CI 0.67 to 1.55).
No increase in risk was evident with increasing exposure.
Conclusions-This study shows no association between exposure to crystalline silica and lung cancer. (...)
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Poussière, Silice, Industrie céramique, Extraction en carrière, Allemagne, Europe, Exposition professionnelle, Facteur risque, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Médecine travail
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Dust, Silica, Ceramics industry, Quarrying, Germany, Europe, Occupational exposure, Risk factor, Human, Respiratory disease, Lung disease, Bronchus disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0206970
Code Inist : 002B11A. Création : 16/11/1999.