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  1. Calculating correct Down's syndrome risks.

    Article - En anglais

    Women having both first trimester nuchal translucency and second trimester serum screening tests are likely to receive two different Down's syndrome risks.

    Neither will be correct, and we describe how to calculate a valid combined risk.

    This uses the reported serum-based risk and a likelihood ratio derived from the nuchal translucency report.

    Tables, figures and examples are provided to aid the calculation of the likelihood ratio from either the nuchal translucency in multiples of the normal median, the nuchal translucency and crown-rump length in millimetres, or the reported prior and nuchal translucency-based risks.

    Mots-clés Pascal : Mongolisme, Gestation, Méthodologie, Association, Exploration ultrason, Premier trimestre, Marqueur biologique, Plasma sanguin, Deuxième trimestre, Méthode calcul, Diagnostic, Prénatal, Risque, Homme, Femelle, Foetus, Epidémiologie, Aberration chromosomique, Aneuploïdie, Maladie congénitale

    Mots-clés Pascal anglais : Down syndrome, Pregnancy, Methodology, Association, Sonography, First trimester, Biological marker, Blood plasma, Second trimester, Computing method, Diagnosis, Prenatal, Risk, Human, Female, Fetus, Epidemiology, Chromosomal aberration, Aneuploidy, Congenital disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0206318

    Code Inist : 002B20F01. Création : 16/11/1999.