Antimalarial prophylaxis : Use and adverse events in visitors to the Kruger National Park.
To determine the use of antimalarial prophylaxis and the relative frequency of adverse events with different regimens in visitors to the Kruger National Park.
Retrospective postal survey of a cohort of 7 397 visitors during April 1996.
Telephonic interviews were conducted with all respondents who reported neuropsychiatry adverse events necessitating medical attention, and their medical caregivers.
The most commonly used regimens were chloroquine and proguanil in combination (C & P) (35.6%) and mefloquine (18.4%). However, non-recommneded regimens were also used by travellers to this chloroquine-resistant area, including chloroquine alone (15.7%). Adverse events were reported by 23.8% of travellers and were more common in the C & P group than the mefloquine group (28.9% v. 25.0%, P=0.0100).
Gastro-intestinal side-effects were significantly more common in the C & P group (nausea (P=0.0170), Diarrhoea (P=0.0008), mouth ulcers (P=0.0000)), while neuropsychiatric side-effects were more common in the mefloquine group (depression (P=0.0000), light-headedness (P=0.0009), anxiety (P=0.0060)). Only 30% of travellers reported using antimalarial drugs both regularly as prescribed and for 4 weeks after leaving the malaria area.
The most commonly reported reason for changing prophylaxis was advice from a physician or pharmacist (41.9%). (...)
Mots-clés Pascal : Paludisme, Protozoose, Parasitose, Infection, Chimioprophylaxie, Antipaludique, Evaluation, Fréquence, Utilisation, Effet secondaire, Passager, Parc national, République Sud Africaine, Afrique, Questionnaire, Homme
Mots-clés Pascal anglais : Malaria, Protozoal disease, Parasitosis, Infection, Chemoprophylaxis, Antimalarial, Evaluation, Frequency, Use, Secondary effect, Passenger, National park, South Africa(Republic), Africa, Questionnaire, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0204964
Code Inist : 002B02S06. Création : 16/11/1999.