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  1. Changes in liver-derived enzymes and self-reported alcohol consumption : A 1-year follow-up study in Denmark.

    Article - En anglais


    The association between alcohol intake and liver disease is well known, but little is known about alcohol consumption and changes in liver-derived enzymes within I year.

    In a 1-year follow-up study we examined changes in liver-derived enzymes and their association with self-reported alcohol consumption.


    We recorded liver-derived enzyme values, self-reported alcohol consumption. and potential confounder variables at base line and at a 1-year follow-up in a representative sample of 822 persons (aged 30-50 years) from the survey of The Ebeltoft Health Promotion Project in Denmark, by using questionnaires, health examinations, and blood samples.


    The prevalence of increased liver-derived enzyme values was 11.1% at base line and 11.8% at the 1-year follow-up.

    The incidence rate of increased liver-derived enzyme values was 5.1 per 100 person-years, and 34% of the cases of increased liver-derived enzyme values returned to normal within I year.

    We found an odds ratio of 4.0 for men and 8.0 for women of developing increased liver-derived enzyme values if alcohol consumption was more than 21 units a week.

    The risk seemed to be dose-dependent.


    The prevalence of increased liver-derived enzyme values in the population was high and increased slightly during the study period. (...)

    Mots-clés Pascal : Consommation, Ethanol, Boisson alcoolisée, Effet biologique, Variation, Transaminases, Transferases, Enzyme, Foie, Prévalence, Epidémiologie, Homme, Danemark, Europe, Toxicomanie, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Consumption, Ethanol, Alcoholic beverage, Biological effect, Variations, Transaminases, Transferases, Enzyme, Liver, Prevalence, Epidemiology, Human, Denmark, Europe, Drug addiction, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0202498

    Code Inist : 002B13C03. Création : 16/11/1999.