The association between alcohol intake and liver disease is well known, but little is known about alcohol consumption and changes in liver-derived enzymes within I year.
In a 1-year follow-up study we examined changes in liver-derived enzymes and their association with self-reported alcohol consumption.
We recorded liver-derived enzyme values, self-reported alcohol consumption. and potential confounder variables at base line and at a 1-year follow-up in a representative sample of 822 persons (aged 30-50 years) from the survey of The Ebeltoft Health Promotion Project in Denmark, by using questionnaires, health examinations, and blood samples.
The prevalence of increased liver-derived enzyme values was 11.1% at base line and 11.8% at the 1-year follow-up.
The incidence rate of increased liver-derived enzyme values was 5.1 per 100 person-years, and 34% of the cases of increased liver-derived enzyme values returned to normal within I year.
We found an odds ratio of 4.0 for men and 8.0 for women of developing increased liver-derived enzyme values if alcohol consumption was more than 21 units a week.
The risk seemed to be dose-dependent.
The prevalence of increased liver-derived enzyme values in the population was high and increased slightly during the study period. (...)
Mots-clés Pascal : Consommation, Ethanol, Boisson alcoolisée, Effet biologique, Variation, Transaminases, Transferases, Enzyme, Foie, Prévalence, Epidémiologie, Homme, Danemark, Europe, Toxicomanie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Consumption, Ethanol, Alcoholic beverage, Biological effect, Variations, Transaminases, Transferases, Enzyme, Liver, Prevalence, Epidemiology, Human, Denmark, Europe, Drug addiction, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0202498
Code Inist : 002B13C03. Création : 16/11/1999.