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  1. Molecular epidemiology of human cancer.

    Article, Communication - En anglais

    International Congress of Toxicology. Paris, FRA, 1998/07/05.

    A challenging goal of molecular epidemiology is to identify an individual's risk of cancer.

    Molecular epidemiology integrates molecular biology, in vitro and in vivo laboratory models, biochemistry, and epidemiology to infer individual cancer risk.

    Molecular dosimetry of carcinogen exposure is an important facet of molecular epidemiology and cancer risk assessment.

    Carcinogen macromolecular adduct levels, cytogenetic alterations and somatic cell mutations can be measured to determine the biologically-effective doses of carcinogens.

    Molecular epidemiology also explores host cancer susceptibilities, such as carcinogen metabolism, DNA repair, and epigenetic and genetic alterations in tumor suppressor genes, p53 is a prototype tumor suppressor gene and is well suited for analysis of mutational spectrum in human cancer.

    The analyses of germline and somatic mutation spectra of the p53 tumor suppressor gene provide important clues for cancer risk assessment in molecular epidemiology.

    For example, characteristic p53 mutation spectra have been associated with :

    • dietary aflatoxin B1 exposure and hepatocellular carcinoma ;

    • sunlight exposure and skin carcinoma ;

    • and cigarette smoking and lung cancer.

    The mutation spectrum also reveals those p53 mutants that provide cells with a selective clonal-expansion advantage during the multistep process of carcinogenesis. (...)

    Mots-clés Pascal : Epidémiologie moléculaire, Homme, Tumeur maligne, Carcinogenèse, Facteur risque, Gène suppresseur tumeur, Gène TP53

    Mots-clés Pascal anglais : Molecular epidemiology, Human, Malignant tumor, Carcinogenesis, Risk factor, Tumor suppressor gene, TP53 Gene

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0201591

    Code Inist : 002B04E05. Création : 16/11/1999.