Geography of intestinal permeability and absorption.
Background-Intestinal morphology and function vary geographically.
Aims-These functions were assessed in asymptomatic volunteers in European, North American, Middle Eastern, Asian, African, and Caribbean countries.
Methods-Five hour urine collections were obtained from each subject following ingestion of a 100 ml iso-osmolar test solution containing 3-0-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose after an overnight fast, to assess active (3-0-methyl-D-glucose) and passive (D-xylose) carrier mediated, and non-mediated (L-rhamnose) absorption capacity, as well as intestinal permeability (lactulose : rhamnose ratio).
A comparison of results for subjects from tropical countries (n=218) with those resident in the combined temperate and subtropical region (Europe, United States, Qatar) (n=224) showed significant differences.
Residents in tropical areas had a higher mean lactulose : rhamnose ratio and lower mean five hour recoveries of 3-0-methyl-D-glucose, D-xylose, and L-rhamnose, indicating higher intestinal permeability and lower absorptive capacity.
Investigation of visiting residents suggested that differences in intestinal permeability and absorptive capacity were related to the area of residence.
Subjects from Texas and Qatar, although comprised of several ethnic groups and resident in a subtropical area, showed no significant difference from European subjects. (...)
Mots-clés Pascal : Absorption, Intestin, Variation géographique, Origine ethnique, Effet biologique, Perméabilité, Exploration, Homme, Appareil digestif
Mots-clés Pascal anglais : Absorption, Gut, Geographical variation, Ethnic origin, Biological effect, Permeability, Exploration, Human, Digestive system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0201154
Code Inist : 002A17C. Création : 16/11/1999.