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  1. The genetics of endometriosis.

    Article, Communication - En anglais

    Schellekens Symposium. The Hague, NLD, 1998/06/12.

    There is mounting evidence that endometriosis is inherited as a complex trait, like diabetes or asthma.

    This implies there are environmental factors, such as dioxin, that are interacting with multiple genetic susceptibility loci to produce the phenotype.

    The Oxford Endometriosis Gene (OXEGENE) study, an international collaborative project seeks to identify the susceptibility loci using linkage analysis ; the aim then is to use positional cloning techniques to identify genes that predispose women to the disease.

    Analysis of the biochemical function of the gene products will lead to a better understanding of the pathophysiology and aetiology of endometriosis.

    New therapies may be designed based upon knowledge of the gene function and disease associated genetic markers may be used to identify women at high risk of developing the disease.

    Mots-clés Pascal : Endométriose, Gène, Toxicité, Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Santé et environnement, Epidémiologie, Génétique, Facteur risque, Hérédité, Homme, Femelle, Appareil génital femelle pathologie, Utérus pathologie

    Mots-clés Pascal anglais : Endometriosis, Gene, Toxicity, Health and environment, Epidemiology, Genetics, Risk factor, Inheritance(genetics), Human, Female, Female genital diseases, Uterine diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0196738

    Code Inist : 002B20C01. Création : 16/11/1999.