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  1. Fulltext. Smoking and the occurrence of Alzheimer's disease : Cross-sectional and longitudinal data in a population-based study.

    Article - En anglais


    The authors tested the hypothesis that smoking exerts a protective effect on Alzheimer's disease or dementia in a population-based cohort of 668 people aged 75-101 years (Sweden).

    Smoking was negatively associated with prevalent Alzheimer's disease (adjusted odds ratio=0.6,95% confidence interval 0.4-1.1) and dementia (adjusted odds ratio=0.6,95% confidence interval 0.4-1.0).

    Over 3-year follow-up (1989-1992), the hazard ratios of incident Alzheimer's disease and dementia due to smoking were 1.1 (95% confidence interval 0.5-2.4) and 1.4 (95% confidence interval 0.8-2.7).

    Mortality over 5-year follow-up was greater among smokers in demented (hazard ratio=3.4) than nondemented (hazard ratio=0.8) subjects.

    Smoking does not seem protective against Alzheimer's disease or dementia, and the cross-sectional association might be due to differential mortality.

    Mots-clés Pascal : Démence Alzheimer, Tabagisme, Epidémiologie, Incidence, Prévalence, Facteur risque, Personne âgée, Homme, Suède, Europe, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative

    Mots-clés Pascal anglais : Alzheimer disease, Tobacco smoking, Epidemiology, Incidence, Prevalence, Risk factor, Elderly, Human, Sweden, Europe, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0196416

    Code Inist : 002B17G. Création : 16/11/1999.