The incidence of human immunodeficiency virus type 1 (HIV-1) infection among opiate users was determined in a retrospective cohort of 436 patients with multiple admissions to the only inpatient drug treatment program in northern Thailand between October 1993 and September 1995.
During 323.4 person-years of follow-up, 60 patients presenting for detoxification acquired HIV-1 infection, for a crude incidence rate of 18.6 per 100 person-years (95% confidence interval 14.4-23.9).
All seroconverters were male.
HIV-1 incidence varied by the current route of drug administration : 31.3 per 100 person-years for injectors and 2.8 per 100 person-years for noninjectors (smoking and ingestion).
Significant differences were found by ethnicity : HIV-1 incidence was 29.3 per 100 person-years for Thai lowlanders and 8.5 per 100 person-years for hilltribes.
Multivariate relative risk estimates showed that injecting opiates (vs. use by other routes), being unmarried, being under age 40 years, being a Thai lowlander, having a primary and secondary education, and being employed in the business sector were each independently associated with human immunodeficiency virus seroconversion.
This HIV-1 incidence rate is double that reported for Bangkok and suggests that prevention and control programs for drug users need to be expanded throughout Thailand. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Dépistage, Homme, Toxicomanie, Drogue illicite, Opiacés, Ethnie, Thaïlande, Asie, Epidémiologie, Incidence, Etude cohorte, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Medical screening, Human, Drug addiction, Illicit drug, Opiates, Ethnic group, Thailand, Asia, Epidemiology, Incidence, Cohort study, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0192653
Code Inist : 002B05C02D. Création : 16/11/1999.