To understand the intrafamilial transmission and the existing risk factors related to HCV infection in subjects confirmed anti-HCV positive, their sexual partners and household contacts in Friuli.
We enrolled all the subjects that were consecutively identified as HCV positive during routine laboratory testing in six health districts and their household contacts.
From each subject we obtained a blood sample, demographic data and a medical history including the existence of risk factors for HCV.
Antibodies to HCV were detected employing a commercially available second-generation enzyme immunoassay (EIA) ; positive serum specimens were retested using a second-generation recombinant immunoblot assay (RIBA-2).
We recruited 743 subjects. 229 first subjects identified as HCV positive and 514 household contacts.
There were no statistically significant differences in positivity among household contacts.
Analysing intracouple transmission we found no significant differences by gender in couples both with and without parenteral risk factors.
We found, both with univariate and multivariate analysis, as statistically significant risk factors in all the subjects : age older than 60, blood transfusions (particularly those performed before 1984). surgical procedures such as abortion and/or uterine curettage. history of HBV infection, intravenous drug use, and tattooing. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Homme, Italie, Europe, Epidémiologie, Facteur risque, Transmission homme homme, Milieu familial, Etude multicentrique, Evaluation, Etat sanitaire, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Human, Italy, Europe, Epidemiology, Risk factor, Transmission from man to man, Family environment, Multicenter study, Evaluation, Health status, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0192612
Code Inist : 002B05C02G. Création : 16/11/1999.