The current study was designed to elucidate risk factors associated with the development of cervical cancer during the course of routine Papanicolaou smear screening (rapid-onset cervical cancer).
Four hundred eighty-three women diagnosed with invasive cervical cancer, representing 73% of all such tumors diagnosed in Connecticut between 1985 and 1990, were studied.
Papanicolaou smear screening and risk factor information was obtained by questionnaire and physician record review.
Results from human papillomavirus deoxyribonucleic acid testing by polymerase chain reaction of tumor samples were available for 278 study participants.
Prediagnostic Papanicolaou smear slides were reviewed for 67% of cases with a screening history.
Screening history information, slide review, and questionnaire data were used to classify women as having rapid-onset cervical cancer (n=43), possible rapid-onset cervical cancer (n=111), or normal-onset cervical cancer (n=329).
Compared with normal-onset cases, rapid-onset cases tended to be younger (P=001) and were more likely to be white (P=002), diagnosed with adenocarcinomas or adenosquamous carcinomas (P=001), and diagnosed with early-stage disease (P=001).
Cases diagnosed as possible rapid-onset disease tended to have a profile that was intermediate to that observed for rapid-onset and normal-onset cases.
Human papillomavirus deoxyribonucleic acid was detected in 75.2% of cases tested. (...)
Mots-clés Pascal : Tumeur maligne, Col utérus, Frottis cervical, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Epidémiologie, Facteur risque, Homme, Femelle, Etats Unis, Amérique du Nord, Amérique, Appareil génital femelle pathologie, Col utérus pathologie
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Cervical smear, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Epidemiology, Risk factor, Human, Female, United States, North America, America, Female genital diseases, Uterine cervix diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0192260
Code Inist : 002B20C02. Création : 16/11/1999.