Pneumonia is the most common fatal hospital-acquired infection, with attributable mortality rates ranging from 30 to 60%. Rapid initiation of optimal antimicrobial therapy is essential for obtaining treatment success.
In this report the antimicrobial susceptibility of 556 strains from the lower respiratory tract were collected by the SENTRY Antimicrobial Surveillance Program (1997).
These strains were isolated from hospitalized patients faith pneumonia in 10 Latin American centers (6 countries) as part of this 68-center worldwide program.
The isolates were susceptibility tested against more than 70 drugs (35 reported) by the reference broth microdilution method.
Klebsiella pneumoniae and Escherichia coli phenotypically consistent with extended spectrum bêta-lactamase (ESBL) production were characterized further by ribotyping and pulsed-field gel electrophoresis.
The five most frequently isolated species were (n/%) :
Pseudomonas aeruginosa (149/26.8%),
Staphylococcus aureus (127/22.8%),
Acinetobacter spp. (66/11.9%),
Klebsiella spp. (56/10/1%), and Enterobacter spp. (40/7.2%). P. aeruginosa demonstrated high rates of resistance to a majority of the antimicrobial drugs tested.
Carbapenems, amikacin, and piperacillin/tazobactam demonstrated the highest susceptibility rates (73.8-77.2%) against P. aeruginosa, however the lowest resistance rate was observed for cefepime (6.7%). Acinetobacter spp. (...)
Mots-clés Pascal : Homme, Surveillance sanitaire, Programme sanitaire, Génotype, DNA ribosomique, Répartition géographique, Prévalence, Test sensibilité médicamenteuse, Antibactérien, Antibiotique, Concentration minimale inhibitrice, Sensibilité résistance, Pneumonie, Résistance multiple, Bactériose, Infection, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Human, Sanitary surveillance, Sanitary program, Genotype, Ribosomal DNA, Geographic distribution, Prevalence, Drug susceptibility test, Antibacterial agent, Antibiotic, Minimum inhibitory concentration, Sensitivity resistance, Pneumonia, Multiple resistance, Bacteriosis, Infection, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0191478
Code Inist : 002B05B02E. Création : 16/11/1999.