In a previous study we have shown that transplacental transfer of hepatitis A antibodies to preterm infants does not differ from that observed in full-term infants.
This follow-up study was designed to investigate the decline of hepatitis A virus (HAV) antibodies during the first 7 months of life in full-term and preterm infants, in an endemic region for hepatitis A. Two hundred and fifty newborn infants - 147 full-term and 103 preterm infants - were enrolled.
Blood samples from the infants were taken at birth, and at 3 and 7 months of age.
Anti-HAV titers were determined by ELISA.
A concentration of >= 1 : 20 mIU/ml was considered protective.
Protective hepatitis A antibodies were present at birth in 48.3% of all full-term and 49.5% of all premature infants.
By the age of 7 months only 13% of full-term and 21.7% of preterm infants still had protective titers.
For the seropositive full-term infants the geometric mean titers (GMT) were 15,698,6,107 and 345 at birth, 3 months and 7 months, respectively, and for preterm infants, 10,378,2,307 and 225 at birth, 3 months and 7 months, respectively.
Significant differences in GMT between preterm and full-term infants were found at birth and at 3 months of age (P<0.05).
In a region endemic for hepatitis A, low levels of anti-HAV at 7 months of age may justify trials on infant vaccination since this is the most effective way to eliminate hepatitis A from circulation.
Mots-clés Pascal : Virus hépatite A, Hepatovirus, Picornaviridae, Virus, Anticorps, Sang, Prématuré, Enfant, Homme, Taux concentration, Séropositivité, Endémie, Région, Hépatite virale A, Virose, Infection, Immunisation passive, Israël, Asie, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Hepatitis A virus, Hepatovirus, Picornaviridae, Virus, Antibody, Blood, Premature, Child, Human, Concentration factor, Seropositivity, Endemy, Region, Viral hepatitis A, Viral disease, Infection, Passive immunization, Israel, Asia, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0191061
Code Inist : 002B05C02G. Création : 16/11/1999.