The occurrence of epileptic seizures during onchocercal infestation has been suspected.
Epidemiologic studies are necessary to confirm the relation between onchocerciasis and epilepsy.
A matched case-control study was conducted in dispensaries of three northwestern towns of the Central African Republic.
Each epileptic case was matched against two nonepileptic controls on the six criteria of sex, age (±5 years), residence, treatment with ivermectin, date of last ivermectin dose, and the number of ivermectin doses.
Onchocerciasis was defined as at least one microfilaria observed in iliac crest skin snip biopsy.
A total of 561 subjects (187 cases and 374 controls) were included in the study.
Of the epileptics, 39.6% had onchocerciasis, as did 35.8% of the controls.
The mean dermal microfilarial load was 26 microfilariae per mg of skin (standard deviation, 42) in the epileptics and 24 microfilariae per mg of skin (standard deviation, 48) in the controls.
This matched case-control study found some relation (odds ratio=1.21,95% confidence interval 0.81-1.80), although it was nonstatistically significant.
Mots-clés Pascal : Onchocercose, Filariose, Nématodose, Helminthiase, Parasitose, Infection, Homme, Association, Epilepsie, République centrafricaine, Afrique, Epidémiologie, Prévalence, Etude cas témoin, Peau pathologie, Oeil pathologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Onchocerciasis, Filariosis, Nematode disease, Helminthiasis, Parasitosis, Infection, Human, Association, Epilepsy, Central African Republic, Africa, Epidemiology, Prevalence, Case control study, Skin disease, Eye disease, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0190874
Code Inist : 002B05E03B4C. Création : 16/11/1999.