To investigate whether diuretic medication use increases risk of renal cell carcinoma (RCC), the authors conducted a case-control study of health maintenance organization members in western Washington State.
Cases (n=238) diagnosed between January 1980 and June 1995 were compared with controls (n=616) selected from health maintenance organization membership files.
The computerized health maintenance organization pharmacy database provided information on medications prescribed after March 1977.
Additional exposure information was collected from medical records.
For women, use of diuretics was associated with increased risk of RCC (odds ratio (OR)=1.8,95% confidence interval (Cl) 1.0-3.1), but the association was not independent of a diagnosis of hypertension (adjusted for hypertension, OR=1.1,95% Cl 0.5-2.1).
Similarly, nondiuretic antihypertensive use was associated with increased risk, but only when unadjusted for hypertension.
For men, neither diuretic nor nondiuretic antihypertensive use was associated with risk of RCC.
A diagnosis of hypertension was clearly associated with RCC risk for women (OR=2.5,95% Cl 1.2-5.1), but not men (OR=1.3,95% Cl 0.7-2.5).
High systolic and diastolic blood pressures were associated with increased risk in both sexes.
These results do not support the hypothesis that use of diuretic medication increases RCC risk ; they are more consistent with an association between RCC and high blood pressure.
Mots-clés Pascal : Hypertension artérielle, Homme, Sexe, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Etude cas témoin, Traitement, Chimiothérapie, Diurétique, Risque, Toxicité, Adénocarcinome, Rein, Appareil circulatoire pathologie, Tumeur maligne, Rein pathologie, Appareil urinaire pathologie
Mots-clés Pascal anglais : Hypertension, Human, Sex, United States, North America, America, Epidemiology, Case control study, Treatment, Chemotherapy, Diuretic, Risk, Toxicity, Adenocarcinoma, Kidney, Cardiovascular disease, Malignant tumor, Kidney disease, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0190872
Code Inist : 002B14D01. Création : 16/11/1999.