logo BDSP

Base documentaire


  1. Fulltext. Hypertension, antihypertensive medication use, and risk of renal cell carcinoma.

    Article - En anglais

    Fulltext.

    To investigate whether diuretic medication use increases risk of renal cell carcinoma (RCC), the authors conducted a case-control study of health maintenance organization members in western Washington State.

    Cases (n=238) diagnosed between January 1980 and June 1995 were compared with controls (n=616) selected from health maintenance organization membership files.

    The computerized health maintenance organization pharmacy database provided information on medications prescribed after March 1977.

    Additional exposure information was collected from medical records.

    For women, use of diuretics was associated with increased risk of RCC (odds ratio (OR)=1.8,95% confidence interval (Cl) 1.0-3.1), but the association was not independent of a diagnosis of hypertension (adjusted for hypertension, OR=1.1,95% Cl 0.5-2.1).

    Similarly, nondiuretic antihypertensive use was associated with increased risk, but only when unadjusted for hypertension.

    For men, neither diuretic nor nondiuretic antihypertensive use was associated with risk of RCC.

    A diagnosis of hypertension was clearly associated with RCC risk for women (OR=2.5,95% Cl 1.2-5.1), but not men (OR=1.3,95% Cl 0.7-2.5).

    High systolic and diastolic blood pressures were associated with increased risk in both sexes.

    These results do not support the hypothesis that use of diuretic medication increases RCC risk ; they are more consistent with an association between RCC and high blood pressure.

    Mots-clés Pascal : Hypertension artérielle, Homme, Sexe, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Etude cas témoin, Traitement, Chimiothérapie, Diurétique, Risque, Toxicité, Adénocarcinome, Rein, Appareil circulatoire pathologie, Tumeur maligne, Rein pathologie, Appareil urinaire pathologie

    Mots-clés Pascal anglais : Hypertension, Human, Sex, United States, North America, America, Epidemiology, Case control study, Treatment, Chemotherapy, Diuretic, Risk, Toxicity, Adenocarcinoma, Kidney, Cardiovascular disease, Malignant tumor, Kidney disease, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0190872

    Code Inist : 002B14D01. Création : 16/11/1999.



Fermeture du portail BDSP le 1er juillet 2019

Madame, Monsieur, utilisateurs du site BDSP et de ses services,

Nous avons le regret de vous informer de la fermeture du portail BDSP le 1er juillet 2019.

Pendant une période de transition de six mois, du 1er janvier au 30 juin 2019, le site et ses services resteront accessibles mais ne seront plus alimentés, ni mis à jour.

Plus précisément, concernant le service "Offres d'emploi", les dernières annonces seront publiées le 18 décembre 2018.

Concernant le service "Annonces de colloques", les dernières annonces seront publiées le 30 novembre 2018.

Nous vous informerons régulièrement sur le devenir des services (archivage ouvert, reprise, arrêt) et nous vous proposerons des réorientations vers des services similaires.

Continuez sur le site en cliquant ICI.

L'équipe de coordination de la BDSP