Double-blind, randomized, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhoea.
In a double-blind, controlled trial with a factorial design, 684 patients (aged 6 months to 2 y ; excludes 6 early dropouts) with acute watery diarrhoea of 3 d or less and some dehydration, who were attending a hospital, were randomly assigned to 4 groups to receive :
(a) vitamin A 4500 mug retinol equivalent daily for 15 d ;
(b) 14.2 mg elemental zinc as acetate for the first 417 patients and 40 mg of the remaining 273 patients randomized to this group for 15 d ;
(c) both vitamin A 4500 mug retinol equivalent and zinc at the above doses daily for 15 d ;
or (d) placebo mixtures for 15 d. Patients were observed in the hospital for 24h and followed up at home for 15 d. All received ascorbic acid 30 mg with each dose of medicine or placebo.
Zinc supplementation was associated with a reduced duration of diarrhoea (13%, p=0.03) and markedly reduced rate (43%, p=0.017) of prolonged diarrhoea (>7 d).
Vitamin A supplementation was associated with a non-significant trend for reduced rate of prolonged diarrhoea (p=0.089).
In conclusion, zinc supplementation as adjunct therapy had a substantial impact on the rate of prolonged diarrhoea and some impact on duration and may be beneficial in children with diarrhoea in developing countries.
Mots-clés Pascal : Diarrhée, Aigu, Nourrisson, Homme, Prévention, Complication, Evolution, Déshydratation, Bengla Desh, Asie, Epidémiologie, Traitement, Chimiothérapie, Randomisation, Essai thérapeutique contrôlé, Zinc, Rétinol, Elément minéral, Appareil digestif pathologie, Intestin pathologie, Trouble équilibre hydroélectrolytique
Mots-clés Pascal anglais : Diarrhea, Acute, Infant, Human, Prevention, Complication, Evolution, Dehydration, Bangladesh, Asia, Epidemiology, Treatment, Chemotherapy, Randomization, Controlled therapeutic trial, Zinc, Retinol, Inorganic element, Digestive diseases, Intestinal disease, Hydroelectrolytic balance disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0190823
Code Inist : 002B02H. Création : 16/11/1999.