Cell-associated infectious HIV-viral load was measured using semi-quantitative microculture techniques to determine its predictive capability for progression to AIDS or survival among HIV-I infected injecting drug users (IDU) and homosexual men (HM).
The authors followed 296 IDU and 240 HM from February 1992 through September 1995 for : (i) death, (ii) AIDS, and (iii) AIDS or bacterial infection.
At baseline, viral load was quantified using microculture techniques to determine infectious units per million peripheral blood mononuclear cells (IUPM).
Data were analyzed using standard statistical methods for survival analysis.
Of the 536 total participants, 106 died (20%), and 98 of the 481 AIDS-free participants developed AIDS (20%). The relative hazard of AIDS for a viral load of >= 100 IUPM, relative to a negative culture (0 IUPM), was 6.73 (95% CI : 2.23-20.3) after adjusting for risk group, initial CD4-count, and other covariates.
The adjusted relative hazard of death for a viral load of >= 100 IUPM vs. 0 IUPM was 2.57 (95% Cl : 0.97-6.80).
Viral load predicted time to death within the<200 cells/mul CD4+stratum.
The predictive value of viral load on HIV1 progression did not vary by risk group.
These data show that cell associated infectious HIV-I viral load was significantly predictive of progression across risk groups for AIDS and death among those severely immune compromised.
Mots-clés Pascal : SIDA, Virose, Infection, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Homme, Toxicomanie, Prise risque, Homosexualité, Comportement sexuel, Facteur prédictif, Evolution, Survie, Lymphocyte T, Réaction chaîne polymérase, Technique ELISA, Charge virale, Immunopathologie, Immunodéficit, Lymphocyte CD4
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, United States, North America, America, Epidemiology, Human, Drug addiction, Risk taking, Homosexuality, Sexual behavior, Predictive factor, Evolution, Survival, T-Lymphocyte, Polymerase chain reaction, ELISA assay, Viral load, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0190708
Code Inist : 002B05C02D. Création : 16/11/1999.