The Prevention of Liver Diseases on the Threshold of the Third Millennium. International Meeting. Capri, ITA, 1998/05/21.
In 1983, a pilot project of universal hepatitis B vaccination was introduced in a hyperendemic area in southern Italy (Afragola) and is ongoing to date.
In this area before the start of vaccination, we found significant evidence of HBV endemicity :
the acute viral hepatitis B incidence in the general population averaged 63/100,000 ;
the HBsAg and anti-HBc prevalence rates were 13.4% and 66.9%, respectively ;
there was involvement of hepatitis B virus (HBV) in 48.1% of chronic liver pathologies (46.3% in chronic viral hepatitis, 49.5% in cirrhosis and 71.7% in hepatocellular carcinoma cases).
We studied the acute viral hepatitis incidence during the vaccination period from 1983 to 1997 and compared the HBsAg and anti-HBc prevalences in 1978 to those in 1997, after 15 years of vaccination.
The HBV-related chronic pathology prevalence was also studied.
We found a remarkable drop in the acute viral hepatitis incidence, from an average annually of 63/100,000 in the five years before vaccination to 3/100,000 in the last five years of vaccination.
In addition, the HBsAg carrier prevalence in the general population decreased from 13.4% in 1978 to 3.7% in 1997.
The percentage dropped in children and adolescents from 6.8% to 0.7%, in young people from 10.2% to 1.1% and in adults from 15.8% to 4.0%. The anti-HBc carrier prevalence, found to be 66.9% in 1978, was 34.2% in 1997. (...)
Mots-clés Pascal : Virus hépatite B, Orthohepadnavirus, Hepadnaviridae, Virus, Homme, Epidémiologie, Prévalence, Programme sanitaire, Prévention, Vaccination, Hépatite virale B, Virose, Infection, Appareil digestif pathologie, Foie pathologie, Italie, Europe, Europe Sud
Mots-clés Pascal anglais : Hepatitis B virus, Orthohepadnavirus, Hepadnaviridae, Virus, Human, Epidemiology, Prevalence, Sanitary program, Prevention, Vaccination, Viral hepatitis B, Viral disease, Infection, Digestive diseases, Hepatic disease, Italy, Europe, Southern Europe
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0190673
Code Inist : 002A05C06. Création : 16/11/1999.