Previous cohort studies of fat intake and risk of coronary heart disease (CHD) have been inconsistent, probably due in part to methodological differences and various limitations, including inadequate dietary assessment and incomplete adjustment for total energy intake.
The authors analyzed repeated assessment of diet from the Nurses'Health Study to examine the associations between intakes of four major types of fat (saturated, monounsaturated, polyunsaturated, and trans fats) and risk of CHD during 14 years of follow-up (1980-1994) by using alternative methods for energy adjustment.
In particular, the authors compared four risk models for energy adjustment : the standard multivariate model, the energy-partition model, the nutrient residual model, and the multivariate nutrient density model.
Within each model, the authors compared four different approaches for analyzing repeated dietary measurements : baseline diet only, the most recent diet, and two different algorithms for calculating cumulative average diets.
The substantive results were consistent across all models ; that is, higher intakes of saturated and trans fats were associated with increased risk of CHD, while higher intakes of monounsaturated and polyunsaturated fats were associated with reduced risk.
When nutrients were considered as continuous variables, the four energy-adjustment methods yielded similar associations.
However, the interpretation of the relative risks differed across models. (...)
Mots-clés Pascal : Cardiopathie coronaire, Homme, Femelle, Prévention, Etats Unis, Amérique du Nord, Amérique, Epidémiologie, Régime alimentaire, Alimentation, Méthodologie, Mesure, Corps gras alimentaire, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Human, Female, Prevention, United States, North America, America, Epidemiology, Diet, Feeding, Methodology, Measurement, Edible fat, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0190588
Code Inist : 002B12A03. Création : 16/11/1999.