Obstetric complications and the risk of schizophrenia : A longitudinal study of a National Birth cohort.
Numerous epidemiological studies found an increased risk of schizophrenia among persons exposed to various obstetric complications.
The underlying mechansims are unknown.
To study specific risk factors, as well as sets of risk factors, representing 3 different etiologic mechanisms :
(1) malnutrition during fetal life ;
(2) extreme pre-maturity ;
and (3) hypoxia or ischemia.
In this longitudinal cohort study, information in the National Birth Register was linked to the National Inpatient Register.
We followed up 507 516 children born between 1973 and 1977 with regard to a diagnosis of schizophrenia between 1987 and 1995 (238 cases).
By record linkage, we also had access to data on psychiatric illness in the mother.
Occurrence of schizophrenia was measured by the Mantel-Haenszel test and logistic regression.
A number of specific risk factors were associated with an increased risk of schizophrenia.
The relative risk (95% confidence interval) for preeclampsia was 2.5 (1.4-4.5) ; vacuum extraction, 1.7 (1.1-2.6) ; and malformations, 2.4 (1.2-5.1).
In logistic regression models, we found that indicators of all 3 etiologic mechanisms were associated with increased point estimates of schizophrenia, although at lower risk levels.
Preeclampsia, an indicator of fetal malnutrition, was the only risk factor with statistically significant increased risk after control for all potentially confounding factors. (...)
Mots-clés Pascal : Schizophrénie, Facteur risque, Etude longitudinale, Gestation pathologie, Accouchement pathologie, Complication, Epidémiologie, Etude cohorte, Suède, Europe, Homme, Psychose
Mots-clés Pascal anglais : Schizophrenia, Risk factor, Follow up study, Pregnancy disorders, Delivery disorders, Complication, Epidemiology, Cohort study, Sweden, Europe, Human, Psychosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0189376
Code Inist : 002B18C06A. Création : 16/11/1999.