To determine the effect of different durations of exposure to agricultural chemicals on the activities of the blood enzymes 6-aminolevulinic acid dehydratase (ALAD), superoxide dismutase (SOD), and cholinesterase (ChE) in tobacco field workers.
For this preliminary investigation, 8 volunteers (all smoked tobacco) who were working on a small tobacco farm were monitored over a period of 2 years along with a comparable urban unexposed group (n=4).
During the growing season between 1994 and 1996, dermal and respiratory exposure were determined and blood samples were drawn after the following durations of field work :
(I) preexposure (0 DAY) ;
(2) after I day of field work (1 DAY) - workers reentered fields at 24 h after spraying of acephate and maleic hydrazide ;
(3) after 30 days of field work (postspraying ; 30 DAYS) ;
and (4) Postexposure - no tobacco production.
Activity of ALAD was depressed by 30% after I DAY and there was no further decrease in ALAD activity after 30 DAYS of field work.
SOD activity, in contrast, declined by 29% and 50% after I DAY and 30 DAYS, respectively, as compared with 0-DAY activity and that of the urban control, which was similar to 0-DAY activity (P <= 0.05).
Plasma ChE activity declined by 19% after both 1 and 30 DAYS of exposure/field work.
The activities of all three enzymes were restored to urban control or preexposure levels during postexposure. (...)
Mots-clés Pascal : Exposition professionnelle, Etude cas témoin, Substance croissance végétal, Médecine travail, Etude longitudinale, Insecticide, Pesticide, Agriculture, Tabac, Nicotine, Surveillance biologique, Marqueur biologique, Enzyme, Liquide biologique, Sang, Superoxide dismutase, Oxidoreductases, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Toxicité, Hydrazide organique, Organophosphoré, Homme, Maleic hydrazide, Acephate
Mots-clés Pascal anglais : Occupational exposure, Case control study, Plant growth substance, Occupational medicine, Follow up study, Insecticide, Pesticides, Agriculture, Tobacco, Nicotine, Biological monitoring, Biological marker, Enzyme, Biological fluid, Blood, Superoxide dismutase, Oxidoreductases, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Toxicity, Organic hydrazide, Organophosphorus compounds, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0188002
Code Inist : 002B03G. Création : 16/11/1999.