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  1. Occupational exposure to agricultural chemicals : effect on the activities of some enzymes in the blood of farm workers.

    Article - En anglais

    Objective 

    To determine the effect of different durations of exposure to agricultural chemicals on the activities of the blood enzymes 6-aminolevulinic acid dehydratase (ALAD), superoxide dismutase (SOD), and cholinesterase (ChE) in tobacco field workers.

    Methods 

    For this preliminary investigation, 8 volunteers (all smoked tobacco) who were working on a small tobacco farm were monitored over a period of 2 years along with a comparable urban unexposed group (n=4).

    During the growing season between 1994 and 1996, dermal and respiratory exposure were determined and blood samples were drawn after the following durations of field work :

    • (I) preexposure (0 DAY) ;

    • (2) after I day of field work (1 DAY) - workers reentered fields at 24 h after spraying of acephate and maleic hydrazide ;

    • (3) after 30 days of field work (postspraying ; 30 DAYS) ;

    • and (4) Postexposure - no tobacco production.

    Standard analytical methods were used

    Results :

    Activity of ALAD was depressed by 30% after I DAY and there was no further decrease in ALAD activity after 30 DAYS of field work.

    SOD activity, in contrast, declined by 29% and 50% after I DAY and 30 DAYS, respectively, as compared with 0-DAY activity and that of the urban control, which was similar to 0-DAY activity (P <= 0.05).

    Plasma ChE activity declined by 19% after both 1 and 30 DAYS of exposure/field work.

    The activities of all three enzymes were restored to urban control or preexposure levels during postexposure. (...)

    Mots-clés Pascal : Exposition professionnelle, Etude cas témoin, Substance croissance végétal, Médecine travail, Etude longitudinale, Insecticide, Pesticide, Agriculture, Tabac, Nicotine, Surveillance biologique, Marqueur biologique, Enzyme, Liquide biologique, Sang, Superoxide dismutase, Oxidoreductases, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Toxicité, Hydrazide organique, Organophosphoré, Homme, Maleic hydrazide, Acephate

    Mots-clés Pascal anglais : Occupational exposure, Case control study, Plant growth substance, Occupational medicine, Follow up study, Insecticide, Pesticides, Agriculture, Tobacco, Nicotine, Biological monitoring, Biological marker, Enzyme, Biological fluid, Blood, Superoxide dismutase, Oxidoreductases, Cholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Porphobilinogen synthase, Hydro-lyases, Carbon-oxygen lyases, Lyases, Toxicity, Organic hydrazide, Organophosphorus compounds, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0188002

    Code Inist : 002B03G. Création : 16/11/1999.