Occurrence of urinary tract tumors in miners highly exposed to dinitrotoluene.
Between 1984 and 1997, six cases of urothelial cancer and 14 cases of renal cell cancer occurred in a group of 500 underground mining workers in the copper-mining industry of the former German Democratic Republic, with high exposures to explosives containing technical dinitrotoluene.
Exposure durations ranged from 7 to 37 years, and latency periods ranged from 21 to 46 years.
The incidences of both urothelial and renal cell tumors in this group were much higher than anticipated on the basis of the cancer registers of the German Democratic Republic by factors of 4.5 and 14.3, respectively.
The cancer cases and a representative group of 183 formerly dinitrotoluene-exposed miners of this local industry were interviewed for their working history and grouped into four exposure categories.
This categorization of the 14 renal cell tumor cases revealed no dose-dependency concerning explosives in any of the four exposure categories and was similar to that of the representative group of employees, whereas the urothelial tumor cases were predominantly confined to the high-exposure categories.
Furthermore, all identified tumor patients were genotyped by polymerase chain reaction, using lymphocyte DNA, regarding their genetic status of the polymorphic xenobiotic metabolizing enzymes, including the N-acetyltransferase 2 and the glutathione-S-transferases M1 and T1. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Toluène(dinitro), Explosif, Industrie extractive, Tumeur maligne, Appareil urinaire pathologie, Etude cas témoin, Rétrospective, Facteur risque, Génotype, Phénotype acétylateur, Enzyme, Glutathione transferase, Transferases, Homme
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Dinitrotoluene, Explosives, Mining industry, Malignant tumor, Urinary system disease, Case control study, Retrospective, Risk factor, Genotype, Acetylator phenotype, Enzyme, Glutathione transferase, Transferases, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0187413
Code Inist : 002B14D02. Création : 16/11/1999.