This article reports the results obtained with the biological and environmental monitoring of occupational exposure to cyclohexane using 1,2-cyclohexanediol (1,2-DIOL) and 1.4-DIOL in urine.
The kinetic profile of 1,2-DIOL in urine suggested by a physiologically based pharmacokinetic (PBPK) model was compared with the results obtained in workers.
Individual exposure to cyclohexane was measured in 156 workers employed in shoe and leather factories.
The biological monitoring of cyclohexane exposure was done by measurement of 1,2-DIOL and 1,4-DIOL in urine collected on different days of the working week.
In all. 29 workers provided urine samples on Monday (before and after the work shift) and 47 workers provided biological samples on Thursday at the end of the shift and on Friday morning.
Another 86 workers provided biological samples at the end of the work shift only on Monday or Thursday.
Individual exposure to cyclohexane ranged from 7 to 617 mg/m3 (geometric mean value 60 mg/m3).
Urinary concentrations of 1.2-DIOL (geometric mean) were 3.1,7.6,13.2, and 6.3 mg/g creatinine on Monday (pre-and postshift).
Thursday (postshift) and Friday (pre-shift). respectively.
The corresponding values recorded for 1,4-DIOL were 2.8,5.1,7.8, and 3.7 mg/g creatinine.
A fairly close, statistically significant correlation was found between environmental exposure to cyclohexane and postshift urinary 1.2-DIOL and 1,4-DIOL on Monday. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Cyclohexane, Industrie cuir, Homme, Surveillance biologique, Solvant organique, Marqueur biologique, Liquide biologique, Urine, Métabolite, Teneur air ambiant, Milieu professionnel, Modélisation, Modèle PBPK, Cyclohexanediol
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Cyclohexane, Leather industry, Human, Biological monitoring, Organic solvent, Biological marker, Biological fluid, Urine, Metabolite, Ambient air concentration, Occupational environment, Modeling, Physiologically based pharmacokinetic model
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0186433
Code Inist : 002B03L04. Création : 16/11/1999.