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  1. Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    Article - En anglais


    Some studies suggest that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may affect glucose metabolism and thyroid function.

    To further assess the relation between exposure to TCDD and endocrine function, data from the largest morbidity study of industrial workers exposed to TCDD were examined.

    Methods-A cross sectional study of workers employed>15 years earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two United States chemical plants was conducted.

    The referent group consisted of people with no occupational exposure to phenoxy herbicides and were recruited from the neighbourhoods where the workers lived.


    A total of 281 workers and 260 unexposed referents participated.

    The mean current serum lipid adjusted TCDD concentration among workers was 220 pg/g lipid, and among referents was 7 pg/g lipid (p<0.05), The half life extrapolated TCDD concentrations (the estimated TCDD concentration when occupational exposure to TCDD stopped) among workers averaged 1900 pg/g lipid (range : not detected-30 000 pglg lipid).

    Overall, the prevalence of diabetes mellitus was not significantly different between the workers and referents.

    Also, there was not a significant positive trend between prevalence of diabetes and increasing serum TCDD concentration.

    However, diabetes was found in six of 10 (60%) workers with current serum TCDD concentrations>1500 pg/g lipid. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Dibenzo-p-dioxine(2,3,7,8-tétrachloro), Thyroïde pathologie, Homme, Diabète, Industrie chimique, Facteur risque, Etude cohorte, Relation dose réponse, Toxicité, Evaluation, Endocrinopathie

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Thyroid diseases, Human, Diabetes mellitus, Chemical industry, Risk factor, Cohort study, Dose activity relation, Toxicity, Evaluation, Endocrinopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0186375

    Code Inist : 002B03L06. Création : 16/11/1999.