Seroprevalence of hepatitis A markers in subjects exposed to biological risk.
The seroprevalence of hepatitis A virus antibodies was investigated in a population of 1051 subjects, of whom 376 were controls and 675 were exposed to different degrees of biological risk.
The exposed group was subdivided into subjects at low (242), intermediate (265), and high (168) biological hazard ; all subjects were employed in the biomedical field.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were also determined.
The seroprevalence of positive hepatitis A antibodies was 44.9% in all subjects but was significantly higher in males (50.6%) than in females (34.2%) and increased according to age (25.9% in subjects aged <=40 years and 62.2% in subjects aged>40 years).
No difference related to exposure to the biological risk was observed.
The prevalence of transaminases at levels above normal values (X2=4.079, P<0.05 for AST and X2=4.806, P<0.05 for ALT) and mean values (AST P<0.05 : ALT P<0.001) appeared significant in hepatitis A virus-positive subjects.
On the other hand, excluding individuals with positive hepatitis C virus antibodies (16) and positive hepatitis B virus surface antigen (12), a prevalence of transaminase alterations was not observed, but mean levels of ALT lasted significantly longer in subjects with positive hepatitis A virus antibodies (P<0.01). (...)
Mots-clés Pascal : Médecine travail, Surveillance biologique, Personnel laboratoire, Personnel sanitaire, Contamination biologique, Hépatite virale A, Virose, Infection, Séropositivité, Prévalence, Facteur risque, Etude cas témoin, Homme, Comparaison interindividuelle, Age, Sexe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Occupational medicine, Biological monitoring, Laboratory staff, Health staff, Biological contamination, Viral hepatitis A, Viral disease, Infection, Seropositivity, Prevalence, Risk factor, Case control study, Human, Interindividual comparison, Age, Sex, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0186127
Code Inist : 002B30B01B. Création : 16/11/1999.