Possible preferential metabolism of xylene isomers following occupational exposure to mixed xylenes.
Solvent exposures commonly involve mixtures of substances or mixtures of isomers of a single solvent.
These may be metabolised through common pathways, resulting in the potential for metabolic interactions.
These may then lead to accumulation of solvent or metabolic intermediates, some of which may be toxic.
This paper describes a pilot study conducted to determine the correlation between airborne xylene isomers and the appearance of methylhippuric acid (MHA) isomers in urine of workers exposed mainly to xylene.
The project also aimed to determine whether there is preferential metabolism of any isomer by comparison of the ratios of airborne isomers with the ratios of metabolite isomers appearing in urine.
Subjects and methods
A total of 12 workers (11 male, 1 female) were recruited into this study, with 2 of the participants providing samples on more than one occasion.
Workers included flooring contractors (5), printers (2), chemical manufacturers (2), histology technicians (2) and one householder using a xylene-based varnish.
Subjects were aged between 24 and 48 years (37.6 ± 2.0 years : mean ± SEM).
After giving informed consent, workers provided a prework and postwork urine sample on a midweek work day.
Samples were stored frozen prior to analysis.
Breathing-zone air samples were collected using personal air samplers at 50 ml/min.
Solvents were trapped on activated-charcoal sampling tubes. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Solvant organique, Xylène, Industrie, Toxicocinétique, Métabolisme, Homme, Isomère, Teneur air ambiant, Lieu travail
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Organic solvent, Xylene, Industry, Toxicokinetics, Metabolism, Human, Isomer, Ambient air concentration, Work place
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0185957
Code Inist : 002B03L04. Création : 16/11/1999.