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  1. New vs. old antipsychotics : The Texas experience.

    Article, Communication - En anglais

    National Consensus Conference on the Pharmacoeconomics of Treatment-Resistant Schizophrenia. Dallas, TX, USA, 1997/10/04.

    A study was conducted in Texas state psychiatric facilities of 299 patients with schizophrenia who were taking clozapine, comparing them with 223 matched controls taking traditional neuroleptics.

    From 12 months before until 54 months after clozapine was begun, hospital bed days and the associated costs were determined for both groups.

    The clozapine group had appreciably fewer hospital bed days throughout the study period.

    Substantially fewer clozapine-treated patients than neuroleptic-treated patients required 180 continuous days of hospitalization during the study.

    By 48 months after initiation of clozapine, hospital inpatient costs were $27,850/patient/year lower in the clozapine group than in the traditional neuroleptic group.

    Agranulocytosis occurred in<1% of patients taking clozapine ; all recovered quickly.

    In a separate study, clozapine therapy was shown to produce a 5-fold decrease in the rate of suicide among patients with schizophrenia.

    Administration of clozapine appears to lower the overall cost of treating schizophrenia by reducing the costs associated with hospitalizations.

    Mots-clés Pascal : Schizophrénie, Chimiothérapie, Traitement, Clozapine, Atypique, Etude comparative, Neuroleptique, Psychotrope, Toxicité, Analyse coût, Economie santé, Texas, Etats Unis, Amérique du Nord, Amérique, Homme, Psychose, Dibenzodiazépine

    Mots-clés Pascal anglais : Schizophrenia, Chemotherapy, Treatment, Clozapine, Atypical, Comparative study, Neuroleptic, Psychotropic, Toxicity, Cost analysis, Health economy, Texas, United States, North America, America, Human, Psychosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0185822

    Code Inist : 002B02B03. Création : 16/11/1999.