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  1. Fulltext. Nasal epithelium as a sentinel for airborne environmental pollution.

    Article - En anglais


    A wide range of chemicals, particulate matter, and gaseous air pollutants are present in urban atmospheres and may pose a significant health risk for human populations.

    Nasal passages are the first site of contact of the respiratory tract with the environment and offer significant protection to the lower respiratory tract by conditioning the inspired air.

    This activity, which includes removal of certain pollutants, places the nose at risk of pathological changes, including cancer.

    Mexico City residents are exposed to a complex mixture of air pollutants.

    Based on predicted nasal air flow characteristics, four nasal biopsy sites were selected for study in adult male volunteers from a control low polluted town (n=12) and southwest metropolitan Mexico City permanent residents (n=54).

    Clinical data with emphasis on nasal symptoms and histopathological changes including basal and goblet cell hyperplasia, squamous metaplasia, epithelial dysplasia, and neovascularization were evaluated.

    Immunohistochemical staining was used to assess accumulation of p53 protein.

    Control individuals had no respiratory symptoms and their biopsies were unremarkable.

    Mexico City residents complained of epistaxis, rhinorrea, nasal crusting, dryness, and nasal obstruction.

    Their biopsies showed patchy shortening of cilia, deciliated areas, basal cell hyperplasia, and squamous metaplasia. (...)

    Mots-clés Pascal : Toxicité, Pollution air, Zone urbaine, Mexique, Amérique Centrale, Amérique, Carcinogène, Surveillance biologique, Epithélium olfactif, Nez, Homme, Epidémiologie, Carcinogenèse, Protéine p53, Histopathologie, Immunohistochimie, Mexico

    Mots-clés Pascal anglais : Toxicity, Air pollution, Urban area, Mexico, Central America, America, Carcinogen, Biological monitoring, Olfactory epithelium, Nose, Human, Epidemiology, Carcinogenesis, p53 Protein, Histopathology, Immunohistochemistry

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0185477

    Code Inist : 002B03M02. Création : 16/11/1999.