The clinical pattern of subclinical/silent celiac disease : An analysis on 1026 consecutive cases.
The demographic, clinical, and epidemiological features of subclinical/silent celiac disease in Italy were analyzed in a multicenter study carried out with the participation of 42 centers, in the years between 1990 and 1994.
One thousand twenty-six subclinical/silent patients (644 children and 382 adults, 702 women and 324 men) were considered eligible for the study.
The prevalence of the subclinical/silent form increased significantly during the study both in adults (p<0.001) and in children (p<0.005), but its prevalence was always lower (p<0.001) in children than in adults.
This increase appears more likely due to a greater diagnostic awareness and to a better use of screening than to a higher number of subclinical/silent cases.
Whereas in 1990 a significantly higher proportion (p<0.001) of subclinical/silent celiac patients was diagnosed in Northern Italy rather than in Southern-Insular Italy, both in adults (46.7% vs 17.2%) and in children (22.0% vs 9.0%), in 1994 such a difference was no longer conspicuous.
Both in children and in adults, iron-deficiency anemia appeared to be the most frequent extraintestinal symptom, followed by short stature in children and cutaneous lesions of dermatitis herpetiformis in adults.
In 25.9% of the cases another disease was present, with a significantly higher frequency (p<0.05) in adults (30.1%) than in children (20.7%). (...)
Mots-clés Pascal : Coeliaque maladie, Asymptomatique, Incidence, Association morbide, Facteur risque, Prédisposition, Déterminisme génétique, Répartition géographique, Epidémiologie, Homme, Italie, Europe, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Génétique
Mots-clés Pascal anglais : Coeliac disease, Asymptomatic, Incidence, Concomitant disease, Risk factor, Predisposition, Genetic determinism, Geographic distribution, Epidemiology, Human, Italy, Europe, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0181722
Code Inist : 002B13B03. Création : 16/11/1999.