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  1. The clinical pattern of subclinical/silent celiac disease : An analysis on 1026 consecutive cases.

    Article - En anglais

    OBJECTIVE 

    The demographic, clinical, and epidemiological features of subclinical/silent celiac disease in Italy were analyzed in a multicenter study carried out with the participation of 42 centers, in the years between 1990 and 1994.

    METHODS 

    One thousand twenty-six subclinical/silent patients (644 children and 382 adults, 702 women and 324 men) were considered eligible for the study.

    RESULTS 

    The prevalence of the subclinical/silent form increased significantly during the study both in adults (p<0.001) and in children (p<0.005), but its prevalence was always lower (p<0.001) in children than in adults.

    This increase appears more likely due to a greater diagnostic awareness and to a better use of screening than to a higher number of subclinical/silent cases.

    Whereas in 1990 a significantly higher proportion (p<0.001) of subclinical/silent celiac patients was diagnosed in Northern Italy rather than in Southern-Insular Italy, both in adults (46.7% vs 17.2%) and in children (22.0% vs 9.0%), in 1994 such a difference was no longer conspicuous.

    Both in children and in adults, iron-deficiency anemia appeared to be the most frequent extraintestinal symptom, followed by short stature in children and cutaneous lesions of dermatitis herpetiformis in adults.

    In 25.9% of the cases another disease was present, with a significantly higher frequency (p<0.05) in adults (30.1%) than in children (20.7%). (...)

    Mots-clés Pascal : Coeliaque maladie, Asymptomatique, Incidence, Association morbide, Facteur risque, Prédisposition, Déterminisme génétique, Répartition géographique, Epidémiologie, Homme, Italie, Europe, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Génétique

    Mots-clés Pascal anglais : Coeliac disease, Asymptomatic, Incidence, Concomitant disease, Risk factor, Predisposition, Genetic determinism, Geographic distribution, Epidemiology, Human, Italy, Europe, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0181722

    Code Inist : 002B13B03. Création : 16/11/1999.