Multiresistant non-fermentative Gram-negative bacteria in cystic fibrosis patients : the results of an Italian multicenter study.
We carried out an epidemiological study on 2717 patients seen on a regular basis at Italian Cystic Fibrosis Centers with the aim of defining the prevalence of multiresistant Gram-negative strains in Italy.
We found 272 multiresistant strains out of 1560 Gram-negative strains isolated in 1012 Italian cystic fibrosis patients.
From our results in Italian cystic fibrosis patients we may conclude :
(1) the beta-lactam antibiotics are moderately active ;
ceftazidime is the most efficacious even if 59.9% of multiresistant strains are not sensitive to this drug ;
(2) the aminoglycosides are poorly efficacious ;
93% of multiresistant strains are resistant in vitro to tobramycin ;
and (3) the quinolones, notwithstanding their relatively recent introduction into clinical practice, have very poor activity against multiresistant strains, 89.7% of which are not sensitive.
Mots-clés Pascal : Mucoviscidose, Bactériose, Infection, Bactérie Gram négatif, Résistance traitement, Antibiotique, Epidémiologie, Chimiothérapie, Traitement, Microbiologie, Homme, Italie, Europe, Etude multicentrique, Appareil respiratoire pathologie, Appareil digestif pathologie, Pancréas pathologie, Maladie héréditaire, Métabolisme pathologie
Mots-clés Pascal anglais : Cystic fibrosis, Bacteriosis, Infection, Gram negative bacteria, Negative therapeutic reaction, Antibiotic, Epidemiology, Chemotherapy, Treatment, Microbiology, Human, Italy, Europe, Multicenter study, Respiratory disease, Digestive diseases, Pancreatic disease, Genetic disease, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0176706
Code Inist : 002B11D. Création : 16/11/1999.