Low circulating levels of the adrenal steroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are thought to be associated with increased risk of cardiovascular disease (CVD) in men.
In women, either a positive or null association with CVD has been found.
The nature of the relation between DHEAS and CVD risk factors in women is unclear and is based on cross-sectional data.
We present results from a longitudinal investigation of serum DHEA and DHEAS and cardiovascular disease risk factor in 236 women, initially 50-60 years old, from a population-based prospective (1986-1995) study of the menopausal transition.
We used generalized estimating equations to model the relation of serum DHEA and DHEAS to sys-tolic and diastolic blood pressure and serum levels of total cholesterol, high density lipoprotein cholesterol, and apolipoproteins A and B, adjusting for other factors related to CVD.
Both DHEA and DHEAS were positively related to diastolic and systolic blood pressure, and DHEAS was negatively related to apolipoprotein A. DHEA and DHEAS were also positively related to moking, alcohol use, estrone and estradiol levels, and inversely related to age.
Our results suggest that higher levels of DHEA and DHEAS in middle-aged women may indicate increased CVD risk.
Mots-clés Pascal : Déhydroépiandrostérone, Déhydroépiandrostérone sulfate, Plasma sanguin, Cardiopathie, Facteur risque, Homme, Femelle, Epidémiologie, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Dehydroepiandrosterone, Dehydroepiandrosterone sulfate, Blood plasma, Heart disease, Risk factor, Human, Female, Epidemiology, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0176314
Code Inist : 002B12A03. Création : 16/11/1999.