A hepatitis B mass immunization program was launched in Taiwan in July 1984, beginning with newborns of hepatitis B carrier mothers for the first 2 years of the program, which was then extended to all newborns.
Seroepidemiology was studied in 3 cohorts at age 6 years.
Each cohort consisted of 1500 children proportionally and randomly sampled from those entering elementary school in 1989,1991, and 1993, representing those born 1 year before the program began and years 1 and 3 of the program, respectively.
By RIA, the hepatitis B surface antigen positivity rates in the groups were 10.5%, 6.3%, and 1.7%, respectively ; hepatitis B surface antibody positivity rates were 36.9%, 62.0%, 65.4% ; and hepatitis B infection rates were 25.0%, 15.9%, 4.3%. Thus, universal immunization was more effective in reducing hepatitis B carriage than selective immunization of newborns of carrier mothers only.
The program has proved effective in controlling chronic hepatitis B infection in Taiwan.
Mots-clés Pascal : Virus hépatite B, Orthohepadnavirus, Hepadnaviridae, Virus, Homme, Femelle, Gestation, Nouveau né, Epidémiologie, Programme sanitaire, Immunisation, Porteur, Antigène HBs, Prévalence, Sérologie, Hépatite virale B, Virose, Infection, Appareil digestif pathologie, Foie pathologie, Taiwan, Asie
Mots-clés Pascal anglais : Hepatitis B virus, Orthohepadnavirus, Hepadnaviridae, Virus, Human, Female, Pregnancy, Newborn, Epidemiology, Sanitary program, Immunization, Carrier, Hepatitis B surface antigen, Prevalence, Serology, Viral hepatitis B, Viral disease, Infection, Digestive diseases, Hepatic disease, Taiwan, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0175105
Code Inist : 002A05C06. Création : 16/11/1999.