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  1. Chronic liver disease in Central Harlem : The role of alcohol and viral hepatitis.

    Article - En anglais

    For reasons not yet determined, chronic liver disease (CLD) has been a leading cause of excess morbidity and mortality in central Harlem.

    We conducted a case series and case-control analysis of demographic, clinical, epidemiological, and alcohol-intake-related information from patients with CLD and age-and sex-matched hospitalized control patients.

    Patients'sera were tested for markers of viral hepatitis.

    The presumed etiology of CLD among case-patients was as follows :

    • both alcohol abuse and hepatitis C virus (HCV) infection, 24 persons (46% of case-patients) ;

    • alcohol abuse alone, 15 (29%) ;

    • HCV infection alone, 6 (12%) ;

    • both alcohol abuse and chronic hepatitis B virus (HBV) infection, 3 (6%) ;

    • and 1 each (2%) from : 1) schistosomiasis, 2) sarcoidosis, 3) unknown causes, and 4) alcohol abuse, chronic HBV, and HCV combined.

    In the case-control analysis, patients who had both alcoholism and either HBV (odds ratio [OR] : 6.3 ; 95% CI : 0.5-334) or HCV (OR : 2.9 ; 95% CI : 1.3-6.2) were at increased risk for CLD, whereas patients who had only one of these three factors were not at increased risk for CLD.

    Patients who tested positive for the hepatitis G virus (HGV) did not have a significantly increased risk of CLD, and neither severity of CLD nor mortality was greater among these patients.

    Most patients in central Harlem who had CLD had liver damage from a combination of alcohol abuse and chronic viral hepatitis. (...)

    Mots-clés Pascal : Foie pathologie, Chronique, Incidence, Morbidité, Facteur risque, Alcoolisme, Hépatite virale, Virose, Infection, Virus hépatite B, Orthohepadnavirus, Hepadnaviridae, Virus, Virus hépatite C, Hepacivirus, Flaviviridae, Epidémiologie, Etude cas témoin, Homme, New York, Etats Unis, Amérique du Nord, Amérique, Appareil digestif pathologie

    Mots-clés Pascal anglais : Hepatic disease, Chronic, Incidence, Morbidity, Risk factor, Alcoholism, Viral hepatitis, Viral disease, Infection, Hepatitis B virus, Orthohepadnavirus, Hepadnaviridae, Virus, Hepatitis C virus, Hepacivirus, Flaviviridae, Epidemiology, Case control study, Human, New York, United States, North America, America, Digestive diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0171559

    Code Inist : 002B30A01A2. Création : 16/11/1999.