Epidemiologic studies have shown dietary antioxidants to be inversely correlated with ischemic heart disease.
We investigated whether dietary bêta-carotene, vitamin C, and vitamin E were related to the risk of myocardial infarction (MI) in an elderly population.
The study sample consisted of 4802 participants of the Rotterdam Study aged 55-95 y who were free of MI at baseline and for whom dietary data assessed by a semiquantitative food frequency questionnaire were available.
During a 4-y follow-up period, 124 subjects had an MI.
The association between energy-adjusted bêta-carotene, vitamin C, and vitamin E intakes and risk of Ml was examined by multivariate logistic regression.
Risk of MI for the highest compared with the lowest tertile of bêta-carotene intake was 0.55 (95% CI : 0.34,0.83 ; P for trend=0.013). adjusted for age, sex, body mass index, pack-years. income, education, alcohol intake, energy-adjusted intakes of vitamin C and E, and use of antioxidative vitamin supplements.
(bêta-carotene intakes from supplements were considered, the inverse relation with risk of MI was slightly more pronounced. Stratification by smoking status indicated that the association was most evident in current and former smokers. No association with risk of MI was observed for dietary vitamin C and vitamin E. (...)
Mots-clés Pascal : Bétacarotène, Acide ascorbique, alpha-Tocophérol, Consommation alimentaire, Antioxydant, Epidémiologie, Infarctus, Myocarde, Prévention, Caroténoïde, Vitamine, Alimentation, Comportement alimentaire, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Personne âgée, Homme, Pays Bas, Europe
Mots-clés Pascal anglais : Betacarotene, Ascorbic acid, alpha-Tocopherol, Food intake, Antioxidant, Epidemiology, Infarct, Myocardium, Prevention, Carotenoid, Vitamin, Feeding, Feeding behavior, Cardiovascular disease, Coronary heart disease, Myocardial disease, Elderly, Human, Netherlands, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0170436
Code Inist : 002B12A03. Création : 16/11/1999.