Several polymorphic glutathione S-transferase enzymes are involved in the detoxification of active metabolites of many potential carcinogens from tobacco smoke and may therefore be important in modulating susceptibility to smoking-related cancers.
As part of a hospital-based case-control study performed in France among Caucasian smokers, we studied GSTMI, GSTM3, GSTPI and GSTTI gene polymorphisms in 121 patients with oral cavity and pharyngeal cancers and 172 hospital controls using peripheral blood DNA.
An increase in risk was found among carriers of the GSTPI (AG or GG) genotype (OR 1.6,95% CI 1.0-2.8, p=0.07) or the GSTTI null genotype (OR 2.0,95% CI 1.0-4.0, p=0.05).
The effect of these at-risk genotypes was most marked in subjects with a history of more than 30 years of smoking, among whom the respective ORs were 2.0 (95% Cl 1.0-3.9) and 3.3 (95% Cl 1.3-8.1), though the interaction tests between these genotypes and duration of smoking were not significant.
In contrast, neither the GSTM I null genotype nor the GSTM3 AA genotype was associated with oropharyngeal cancer risk (OR 0.9,95% Cl 0.5-1.5 and OR=1.3,95% Cl 0.7-2.3, respectively).
Our results thus suggest that GSTPI and GSTTI gene polymorphisms modulate susceptibility to smoking-related cancers of the oral cavity and pharynx.
Mots-clés Pascal : Carcinome épidermoïde, Cavité buccale, Pharynx, Glutathione transferase, Transferases, Enzyme, Variabilité génétique, Polymorphisme, Gène, Génotype, Facteur risque, Epidémiologie, Tabagisme, France, Europe, Etude cas témoin, Homme, Stomatologie, Cavité buccale pathologie, Tumeur maligne, Pharynx pathologie, ORL pathologie, Génétique
Mots-clés Pascal anglais : Squamous cell carcinoma, Oral cavity, Pharynx, Glutathione transferase, Transferases, Enzyme, Genetic variability, Polymorphism, Gene, Genotype, Risk factor, Epidemiology, Tobacco smoking, France, Europe, Case control study, Human, Stomatology, Oral cavity disease, Malignant tumor, Pharynx disease, ENT disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0169704
Code Inist : 002B10B01. Création : 16/11/1999.