We evaluated the risk of cancer among 1897 men and 417 women exposed to chloroprene (2-chloro-1,3-butadiene, CP) at a production plant in Yerevan, Armenia, between 1940 and 1988.
The cohort was followed up for cancer incidence for the years 1979-1990 and for cancer mortality for 1979-1988.
In the cohort, incidence and mortality from all cancers were below expectation, but increased incidence (standardized incidence ratio 3.27,95% confidence interval [CI] 1,47-7.27), and mortality (standardized mortality ratio 3.39,95% CI 1.09-10.5) from liver cancer were noticed.
A dose-response relationship was suggested between liver cancer and indices of CP exposure, such as duration of employment, duration of high CP exposure and cumulative exposure to CP.
The risk of other neoplasms was not increased.
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Incidence, Facteur risque, Epidémiologie, Exposition professionnelle, Carcinogène, Mortalité, Etude cohorte, Arménie, Europe Est, Europe, Homme, Médecine travail, Buta-1,3-diène(2-chloro)
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Incidence, Risk factor, Epidemiology, Occupational exposure, Carcinogen, Mortality, Cohort study, Armenia, Eastern Europe, Europe, Human, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0169701
Code Inist : 002B04B. Création : 16/11/1999.