In an exploratory study, levels of cadmium in whole-kidney and liver tissues of 314 subjects from the general population of the province of Quebec (Canada) were measured postmortem.
Frequency distributions of cadmium concentrations were lognormal.
As reported in similar studies, age and especially smoking habits were the main variables affecting cadmium concentrations.
The geometric mean of whole kidney concentrations (wet weight) was 17.62 mug/g, with a minimum concentration of 2.25 mug/g and a maximum of 100.61 mug/g. Mean concentrations of cadmium in kidneys increased with age, reaching a plateau in the group 50 to 59 yr (29.49 mug/g), and falling slowly thereafter.
The geometric mean in liver was 1.53 mug/g, with a maximum concentration of 2.51 mug/g in subjects over 80 yr of age.
Minimum and maximum concentrations were respectively 0.12 mug/g and 12.49 mug/g. These levels of cadmium are rather high for a general population.
Higher levels are found only in Japan and Poland.
However, the most striking feature is the high smokers to nonsmokers ratio (5) obtained for kidney cadmium concentrations, clearly well above values previously reported in the scientific literature.
This study, as in the case of other research done on blood and urine cadmium levels among the general population of the province of Quebec, shows a significant contribution of smoking to the levels of cadmium in tissues and organs. (...)
Mots-clés Pascal : Epidémiologie, Québec, Canada, Amérique du Nord, Amérique, Métal lourd, Polluant, Cadmium, Homme, Age, Fumeur, Non fumeur, Sexe, Accumulation biologique, Foie, Rein, Postmortem, Matériel autopsie
Mots-clés Pascal anglais : Epidemiology, Quebec, Canada, North America, America, Heavy metal, Pollutant, Cadmium, Human, Age, Smoker, Non smoker, Sex, Biological accumulation, Liver, Kidney, Postmortem, Autopsy material
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0168567
Code Inist : 002B03L05. Création : 16/11/1999.