Prospective cohort Study of antioxidant vitamin supplement use and the risk of age-related maculopathy.
In a prospective cohort study, the authors examined whether self-selection for antioxidant vitamin supplement use affects the incidence of age-related maculopathy.
The study population consisted of 21,120 US male physician participants in the Physicians'Health Study I who did not have a diagnosis of age-related maculopathy at baseline (1982).
During an average of 12.5 person-years of follow-up, a total of 279 incident cases of age-related maculopathy with vision loss to 20/30 or worse were confirmed by medical record review.
In multivariate analysis, as compared with nonusers of supplements, persons who used vitamin E supplements had a possible but nonsignificant 13% reduced risk of age-related maculopathy (relative risk=0.87,95 percent confidence interval (Cl) 0.53-1.43), while users of multivitamins had a possible but nonsignificant 10% reduced risk (relative risk=0.90,95% Cl 0.68-1.19).
Users of vitamin C supplements had a relative risk of 1.03 (95% Cl 0.71-1.50).
These observational data suggest that among persons who self-select for supplemental use of antioxidant vitamin C or E or multivitamins, large reductions in the risk of age-related maculopathy are unlikely.
Randomized trial data are accumulating to enable reliable detection of the existence of more plausible small-to-moderate benefits of these agents alone and in combination on age-related maculopathy.
Mots-clés Pascal : Maculopathie, Homme, Prévention, Evaluation, Incidence, Etude cohorte, Chimioprophylaxie, Vitamine E, Supplémentation, Antioxydant, Questionnaire, Etats Unis, Amérique du Nord, Amérique, Oeil pathologie
Mots-clés Pascal anglais : Maculopathy, Human, Prevention, Evaluation, Incidence, Cohort study, Chemoprophylaxis, E-Vitamins, Supplementation, Antioxidant, Questionnaire, United States, North America, America, Eye disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0168556
Code Inist : 002B09I. Création : 16/11/1999.