Serum fructosamine levels can be used to estimate long-term serum glucose values and can be measured in frozen serum.
The authors examined whether fructosamine levels were associated with mortality in a cohort of 9,704 white women (>65 years of age) recruited from September 1986 to October 1988 at four clinical centers in the United States.
A random sample of women who had died during a mean of 6 years of follow-up (n=55) was compared with randomly selected controls (n=276,54 of whom had died).
Fructosamine assays were performed blinded to vital status.
Hazard ratios with 95% confidence intervals were adjusted for age, clinical center, smoking, hypertension, and serum albumin and cholesterol levels.
Each standard deviation (46 mumol) increase in fructosamine level was associated with a 1.3-fold (95% confidence interval (Cl) 1.0-1.6, p=0.04) increased rate of all-cause mortality, including a 1.5-fold (95% CI 1.0-2.1, p=0.03) increase in cardiovascular disease mortality.
Elevated fructosamine levels (>285 mumol/liter) were associated with a 4.3-fold (95% CI 1.6-12, p=0.004) increased rate of cardiovascular mortality ; in women without a history of diabetes, the hazard ratio was 4.6 (95% Cl 1.3-16, p=0.02).
Fructosamine level, or another indicator of glycemia, should be included when the risk of cardiovascular disease among older patients is evaluated.
Mots-clés Pascal : Cardiopathie coronaire, Personne âgée, Homme, Femelle, Race, Etats Unis, Amérique du Nord, Amérique, Facteur risque, Dépistage, Complication, Mortalité, Epidémiologie, Analyse biochimique, Sérum, Appareil circulatoire pathologie, Fructosamine
Mots-clés Pascal anglais : Coronary heart disease, Elderly, Human, Female, Race, United States, North America, America, Risk factor, Medical screening, Complication, Mortality, Epidemiology, Biochemical analysis, Serum, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0168555
Code Inist : 002B12A03. Création : 16/11/1999.