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  1. Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes : prospective twin study.

    Article - En anglais

    Objective To test the hypothesis that non-diabetic dizygotic and monozygotic twin siblings of patients with type 1 diabetes have a similar high prevalence of islet cell autoantibodies, thus suggesting that islet cell autoimmunity is mainly environmentally determined.

    Design Prospective twin study, Setting Two specialist centres for diabetes in the United States.

    Participants Non-diabetic monozygotic twin (n=53), dizygotic twin (n=30), and non-twin (n=149) siblings of patients with type 1 diabetes ; 101 controls.

    Main outcome measures Analysis of progression to diabetes and expression of anti-islet autoantibodies.

    Results Monozygotic twin siblings had a higher risk of progression to diabetes (12/53) than dizygotic twin siblings (0/30 ; P<0.005).

    At the last follow up 22 (41.5%) monozygotic twin siblings expressed autoantibodies compared with 6 (20%) dizygotic twin siblings (P<0.05), 16 (10.7%) non-twin siblings (P<0.0001), and 6 (5.9%) controls (P<0.0001).

    Monozygotic twin siblings expressed multiple (>=2) antibodies more often than dizygotic twin siblings (10/38 v 1/23 ; P<0.05).

    By life table analysis the probability of developing positive autoantibodies was higher among the monozygotic twin siblings bearing the diabetes associated HLA DQ8/DQ2 genotype than in those without this genotype (64.2% (95% confidence interval 32.5% to 96%) v 23.5% (7% to 40%) at 10 years of discordance ; P<0.05). (...)

    Mots-clés Pascal : Diabète, Etude comparative, Déterminisme génétique, Jumeau, Autoimmunité, Cellule, Ilot Langerhans, Evaluation, Homme, Fratrie, Etats Unis, Amérique du Nord, Amérique, Endocrinopathie, Pancréas endocrine pathologie, Génétique, Immunopathologie

    Mots-clés Pascal anglais : Diabetes mellitus, Comparative study, Genetic determinism, Twin, Autoimmunity, Cell, Langerhans islet, Evaluation, Human, Sibling, United States, North America, America, Endocrinopathy, Endocrine pancreatic diseases, Genetics, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0168241

    Code Inist : 002B21E01A. Création : 16/11/1999.