Inconsistent results have been reported from studies evaluating the association of maternal smoking with birth of a Down syndrome child.
Control of known risk factors, particularly maternal age, has also varied across studies.
By using a population-based case-control design (775 Down syndrome cases and 7,750 normal controls) and Washington State birth record data for 1984-1994, the authors examined this hypothesized association and found a crude odds ratio of 0.80 (95% confidence interval 0.65-0.98).
Controlling for broad categories of maternal age (<35 years, >=35 years), as described in prior studies, resulted in a negative association (odds ratio=0.87,95% confidence interval 0.71-1.07).
However, controlling for exact year of maternal age in conjunction with race and parity resulted in no association (odds ratio=1.00,95% confidence interval 0.82-1.24).
In this study, the prevalence of Down syndrome births increased with increasing maternal age, whereas among controls the reported prevalence of smoking during pregnancy decreased with increasing maternal age.
There is a substantial potential for residual confounding by maternal age in studies of maternal smoking and Down syndrome.
After adequately controlling for maternal age in this study, the authors found no clear relation between maternal smoking and the risk of Down syndrome.
Mots-clés Pascal : Mongolisme, Trisomie, Aneuploïdie, Aberration chromosomique, Etats Unis, Amérique du Nord, Amérique, Enfant, Homme, Epidémiologie, Evaluation, Prévalence, Facteur risque, Age mère, Etude cas témoin, Tabagisme, Chromosome G21, Maladie congénitale
Mots-clés Pascal anglais : Down syndrome, Trisomy, Aneuploidy, Chromosomal aberration, United States, North America, America, Child, Human, Epidemiology, Evaluation, Prevalence, Risk factor, Maternal age, Case control study, Tobacco smoking, Chromosome G21, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0168051
Code Inist : 002B23B. Création : 16/11/1999.