Parental cigarette smoking and the risk of acute leukemia in children.
Studies of the relation between parental smoking and childhood leukemia have produced inconsistent results.
In the largest case-control studies of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) conducted to date, the authors evaluated leukemia risk relative to parental self-report of cigarette smoking.
In telephone interviews in which a structured questionnaire was used, parents of 1842 ALL patients, 517 AML patients, and their matched controls were asked about their cigarette smoking habits before, during, and after the pregnancy with the index child.
Risk of leukemia was examined by histologic type, age of the child at diagnosis, immunophenotype (for ALL), and French-American-Britis] morphology group (for AML).
The risk of ALL was not associated with the father's ever having smoked (odds ratio [OR]=1.04,95% confidence interval [CI] 0.90-1.20) or the mother's ever having smoked (OR=1.04,95% CI 0.91-1.19).
Similarly, no significant risk of AML was observed for paternal (OR=0.88,95% CI 0.67-1.16) or maternal smoking (OR=0.95,95% Cl 0.74-1.22).
The relative risk of leukemia was not significantly different from the null for parental smoking in any time period during or around the index pregnancy, nor was it related to the number of cigarettes, the number of years of smoking, or the number of pack-years. (...)
Mots-clés Pascal : Leucémie lymphoblastique, Leucémie myéloblastique, Facteur risque, Tabagisme, Parent, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Enfant, Homme, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Acute myelocytic leukemia, Risk factor, Tobacco smoking, Parent, Epidemiology, United States, North America, America, Child, Human, Acute, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0167616
Code Inist : 002B19B. Création : 16/11/1999.