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  1. Parental cigarette smoking and the risk of acute leukemia in children.

    Article - En anglais

    BACKGROUND

    Studies of the relation between parental smoking and childhood leukemia have produced inconsistent results.

    In the largest case-control studies of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) conducted to date, the authors evaluated leukemia risk relative to parental self-report of cigarette smoking.

    METHODS

    In telephone interviews in which a structured questionnaire was used, parents of 1842 ALL patients, 517 AML patients, and their matched controls were asked about their cigarette smoking habits before, during, and after the pregnancy with the index child.

    Risk of leukemia was examined by histologic type, age of the child at diagnosis, immunophenotype (for ALL), and French-American-Britis] morphology group (for AML).

    RESULTS

    The risk of ALL was not associated with the father's ever having smoked (odds ratio [OR]=1.04,95% confidence interval [CI] 0.90-1.20) or the mother's ever having smoked (OR=1.04,95% CI 0.91-1.19).

    Similarly, no significant risk of AML was observed for paternal (OR=0.88,95% CI 0.67-1.16) or maternal smoking (OR=0.95,95% Cl 0.74-1.22).

    The relative risk of leukemia was not significantly different from the null for parental smoking in any time period during or around the index pregnancy, nor was it related to the number of cigarettes, the number of years of smoking, or the number of pack-years. (...)

    Mots-clés Pascal : Leucémie lymphoblastique, Leucémie myéloblastique, Facteur risque, Tabagisme, Parent, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Enfant, Homme, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Acute lymphocytic leukemia, Acute myelocytic leukemia, Risk factor, Tobacco smoking, Parent, Epidemiology, United States, North America, America, Child, Human, Acute, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0167616

    Code Inist : 002B19B. Création : 16/11/1999.