A case-control study of non-hodgkin lymphoma and exposure to pesticides.
The incidence of non-Hodgkin lymphoma (NHL) has increased in most Western countries during the last few decades.
Immunodefective conditions are established risk factors.
In 1981, the authors reported an increased risk for NHL following exposure to certain pesticides.
The current study was designed to further elucidate the importance of phenoxyacetic acids and other pesticides in the etiology of NHL.
A population-based case-control study in northern and middle Sweden encompassing 442 cases and twice as many controls was performed.
Exposure data were ascertained by comprehensive questionnaires, and the questionnaires were supplemented by telephone interviews.
In total, 404 cases and 741 controls answered the questionnaire.
Univariate and multivariate analyses were performed with the SAS statistical data program.
Increased risk for NHL was found for subjects exposed to herbicides (odds ratio [OR], 1.6 ; 95% confidence interval [CI], 1.0-2.5) and fungicides (OR, 3.7 ; 95% Cl, 1.1-13.0).
Among herbicides, the phenoxyacetic acids dominated (OR, 1.5 ; 95% CI, 0.9-2.4) ; and, when subclassified, one of these, 4-chloro-2-methyl phenoxyacetic acid (MCPA), turned out to be significantly associated with NHL (OR, 2.7 ; 95% CI, 1.0-6.9).
For several categories of herbicides, it was noted that only exposure during the most recent decades before diagnosis of NHL was associated with an increased risk of NHL. (...)
Mots-clés Pascal : Lymphome non hodgkinien, Composé chimique, Pesticide, Solvant organique, Toxicité, Facteur risque, Epidémiologie, Suède, Europe, Etude cas témoin, Homme, Hémopathie maligne, Lymphoprolifératif syndrome, Acétique acide(2-phénoxy)
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Chemical compound, Pesticides, Organic solvent, Toxicity, Risk factor, Epidemiology, Sweden, Europe, Case control study, Human, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0167612
Code Inist : 002B19B. Création : 16/11/1999.