Human papillomavirus (HPV) types 16 and 18 are the major risk factors for cervical carcinoma, whereas HPV types 6 and I I cause benign genital lesions.
We wanted to study the joint effect of simultaneous infections with the oncogenic and non-oncogenic HPV types on risk of subsequent development of cervical carcinoma A cohort of 530,000 women who had donated blood samples to Nordic serum banks between 1973 and 1994 was followed up by linkage to national cancer registries.
We identified 182 prospective cases with invasive cervical carcinoma and selected 538 matched controls at random.
HPV 6,11,16,18 and 33 seropositivity was used as a marker for the different HPV infections, and seropositivity for Chlamydia trachomatis and cotinine were used as markers for risk-taking sexual behavior and smoking respectively.
The adjusted odds ratio (OR) of cervical squamous-cell carcinoma (SCC) was 2.2 for HPV6/1 1 among HPV16 seronegatives and 5.5 for HPV16 among HPV6/11 seronegatives.
Assuming multiplicative joint effect, the expected OR for seropositivity to both HPV6/11 and HPV16 would have been 12, but the observed OR was 1.0. The antagonistic interaction was statistically significant (p=0.001) and present also under deterministic considerations of possible misclassification bias.
Antagonistic interactions were also detected for combinations of HPV16 and HPV18 and of HPV16 and HPV33. (...)
Mots-clés Pascal : Carcinome, Col utérus, Facteur risque, Epidémiologie, Virose, Infection, Papillomavirus humain 16, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Papillomavirus humain 6, Séropositivité, Etude cohorte, Finlande, Europe, Suède, Norvège, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne, Papillomavirus humain 11
Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Risk factor, Epidemiology, Viral disease, Infection, Human papillomavirus 16, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Human papillomavirus 6, Seropositivity, Cohort study, Finland, Europe, Sweden, Norway, Human, Female genital diseases, Uterine cervix diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0166703
Code Inist : 002B20C02. Création : 16/11/1999.