Extensive data are available on nerve agents as they relate to low dose toxicity.
Highly sensitive in vitro and in vivo mutagenicity and clastogenicity screens as well as subchronic toxicity studies in various animal models have been carried out.
The majority of such closely controlled toxicological studies in the United States have been conducted at the National Center for Toxicological Research or at the University of California.
Data available on humans exposed to nerve agents are obtained primarily from human volunteer studies and accidental exposures.
The former consists of experiments conducted by the U.S. Army between 1958 and 1975.
Cases ofaccidental exposures were occupational hazards of chemical munition production workers.
Controlled studies of human exposures, reports of accidental exposures, and animal studies collectively indicate that exposures to OP nerve agents at levels causing no acute signs or symptoms do not produce chronic illness.
Mots-clés Pascal : Organophosphoré, Inhibiteur enzyme, Toxicité, Système nerveux pathologie, Anticholinestérasique, Homme, Dose faible, Article synthèse, Comparaison interspécifique, Acetylcholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme
Mots-clés Pascal anglais : Organophosphorus compounds, Enzyme inhibitor, Toxicity, Nervous system diseases, Anticholinesterase agent, Human, Low dose, Review, Interspecific comparison, Acetylcholinesterase, Carboxylic ester hydrolases, Esterases, Hydrolases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0163801
Code Inist : 002B03L01. Création : 16/11/1999.