The role of lead exposure a risk factor for hypertension is less well defined among women than among men.
This case-control study assessed the relation of blood and bone lead concentrations to hypertension in women.
Cases and controls were a subsample of women from the Nurses'Health Study.
Hypertension was defined as a physician diagnosis of hypertension between 1988 and 1994 or measure systolic blood pressure >=140 mm Hg or diastolic blood pressure >= 90 mm Hg.
Mean (SD) blood lead concentration was 0.15 (0.11) mumol/L ; mean tibia and patella lead concentratikons by K-x-ray fluorescence were 13.3 (9.0) and 17.3 (11.1) mug/g, respectively.
After adjustment for potentially confounding factors, an increase from the 10th and the 90th percentile of patella lead values (25 mug/g) was associated with approximately 2-fold (95% confidence interval=1.1,3.2=increased risk of hypertension.
There was no association between hypertension and either blood or tibia lead concentrations.
These findings support a potentially important role for low-level lead exposure as a risk factor for hypertension among non-occupationally exposed women.
Mots-clés Pascal : Age mûr, Homme, Femelle, Plomb, Hypertension artérielle, Facteur risque, Os, Sang, Concentration, Elément trace, Etude cas témoin, Epidémiologie, Santé et environnement, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Middle age, Human, Female, Lead, Hypertension, Risk factor, Bone, Blood, Concentration, Trace element, Case control study, Epidemiology, Health and environment, United States, North America, America, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0163783
Code Inist : 002B12B05B. Création : 16/11/1999.