Objectives To produce an epidemiological profile of patients with transitional cell carcinoma (TCC) of the bladder living in the city of Bristol (south-west England), to determine if TCC tumorigenesis is linked to possible risk factors (occupational exposure, cigarette smoking, alcohol consumption and coffee consumption) and to assess phenotypic acetylation status and thus determine whether there may be a genetic component to tumour development.
Patients and methods This cross-sectional observational epidemiological study recruited both cases and controls from one-stop haematuria clinics, providing two groups with a similar age and sex distribution.
Before diagnosis, all patients were interviewed by the same researcher and results recorded on a specially designed database questionnaire, to eliminate both recall and investigator bias.
Metabolic studies were also performed before diagnosis.
Results There were significant associations for occupational exposure, cigarette smoking, and beer consumption (but not wine or spirits), but no significant association with coffee consumption.
Slow acetylation status also conferred an increased risk.
There were linear trends in terms of dose-response for both beer and cigarette consumption, although this was significant only for cigarettes.
There was no difference in risk between the use of filtered or unfiltered cigarettes. (...)
Mots-clés Pascal : Carcinome cellule transitionnelle, Vessie urinaire, Incidence, Facteur risque, Exposition professionnelle, Tabagisme, Alcoolisme, Consommation, Café, Acétylation, Déterminisme génétique, Epidémiologie, Homme, Grande Bretagne, Royaume Uni, Europe, Tumeur maligne, Appareil urinaire pathologie, Voie urinaire pathologie, Vessie pathologie, Toxicomanie
Mots-clés Pascal anglais : Transitional cell carcinoma, Urinary bladder, Incidence, Risk factor, Occupational exposure, Tobacco smoking, Alcoholism, Consumption, Coffee, Acetylation, Genetic determinism, Epidemiology, Human, Great Britain, United Kingdom, Europe, Malignant tumor, Urinary system disease, Urinary tract disease, Bladder disease, Drug addiction
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0163639
Code Inist : 002B14D02. Création : 16/11/1999.